In what type of test is the variable of interest the difference between the values of the observatio

In what type of test is the variable of interest the difference between the values of the observations rather than the observations themselves？

A.a test for the equality of variances from 2 independent populations

B.a test for the difference between the means of 2 related populations

C.a test for the difference between the means of 2 independent populations

D.All of the above

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